Cas number: 147403-03-0 Molecular Formula: C24H29N5O3

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  •  Cas number: 147403-03-0  Molecular Formula: C24H29N5O3

PRODUCTS DETAILS

Melting Point 230°C
Density 1.41g/cm³
storage temp 2-8℃
solubility It is almost insoluble in water, and the solubility in ethanol is 5.5 mg/m
optical activity +76.5 degrees (C=1, ethanol)
Appearance white or off-white solid, odorless
is a non peptide, orally effective angiotensin II (AT) receptor antagonist. It has high selectivity towards type I receptor (AT1) and can be competitively antagonized without any stimulating effects. It can also inhibit AT1 receptor mediated aldosterol release from adrenal glomerular cells, but has no inhibitory effect on potassium induced release, indicating its selective effect on AT1 receptors. In vivo experiments on various types of hypertension animal models have shown that has a good antihypertensive effect and has no significant impact on cardiac contractile function and heart rate. No antihypertensive effect on animals with normal blood pressureAntihypertensive drugs.  is an angiotensin II (Ang II) receptor antagonist that selectively blocks the binding of Ang II to AT1 receptors (its specific antagonistic effect on AT1 receptors is about 20000 times greater than that of AT2), thereby inhibiting vascular contraction and aldosterone release, resulting in hypotensive effectsThe recommended starting dose for tablets is 80mg (2 tablets), taken orally once a day. Generally, if ineffective for 4 weeks, the dosage can be increased to 160mg (4 tablets) once a day. According to foreign clinical application data, the maximum dose can reach 320mg (8 tablets) once a day1.Patients with hypertension complicated with diabetes, hypertension complicated with nephropathy or simple diabetes nephropathy, 2.patients with hypertension complicated with heart failure or myocardial infarction

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